Table 2.

Performance comparison among PD-L1 antibodies using Fleiss’ kappa analyses to compare performance and intraclass correlation coefficient (ICC) to compare tumor cell (TC) and immune cell (IC) percentages.

Kappa analyses for antibody performance
	Kappa	95% confidence interval	P Value
SP142 vs. 22C3	0.791	0.660–0.922	<0.001
SP243 vs. E1L3N	0.762	0.631–0.893	<0.001
22C3 vs. E1L3N	0.743	0.612–0.873	<0.001
SP263 vs. SP142	0.724	0.593–0.855	<0.001
SP263 vs. 22C3	0.706	0.575–0.837	<0.001
SP142 vs. E1L3N	0.639	0.508–0.770	<0.001
ICC analyses for TC percentage
	ICC	95% confidence interval	P value
All four clones	0.900	0.870–0.923	<0.001
SP263 vs. E1L3N	0.949	0.933–0.961	<0.001
22C3 vs. E1L3N	0.939	0.918–0.955	<0.001
SP263 vs. 22C3	0.929	0.905–0.947	<0.001
SP142 vs. 22C3	0.619	0.481–0.717	<0.001
SP263 vs. SP142	0.525	0.340–0.652	<0.001
SP142 vs E1L3N	0.500	0.320–0.629	<0.001
ICC analyses for IC percentage
	ICC	95% confidence interval	P value
All four clones	0.805	0.76–0.844	<0.001
22C3 vs. E1L3N	0.866	0.826–0.897	<0.001
SP263 vs. SP142	0.722	0.638–0.786	<0.001
SP263 vs. E1L3N	0.695	0.595–0.769	<0.001
SP142 vs. E1L3N	0.667	0.567–0.744	<0.001
SP263 vs. 22C3	0.567	0.435–0.668	<0.001
SP142 vs. 22C3	0.519	0.376–0.630	<0.001