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. 2019 Jul 24;15(2):237–246. doi: 10.5152/iao.2019.6208

Figure 1.

Figure 1

Study plan. Baseline hearing ABR measurements were obtained on Day 0 before drug administration in all rats. Group I received IP FA (10 mg/kg/day) on Days 1, 2, 3, and 4, and IP CDDP (10 mg/kg/day) on Days 2 and 3, with a cumulative dose of 20 mg/kg. Group II received IP physiological saline (2 mL/day) on Days 1, 2, 3, and 4 and IP CDDP (10 mg/kg/day) on Days 2 and 3, with a cumulative dose of 20 mg/kg. The rats in Group III received IT FA (0.15 mL/day) on Days 1, 2, 3, and 4 and IP CDDP (10 mg/lg/day) on Days 2 and 3. Group IV received IT physiological saline on Days 1, 2, 3, and 4 and IP CDDP (10 mg/kg/day) on Days 2 and 3. Group V received IT FA (0.15 mL/day) on Days 1, 2, 3, and 4. After drug administration, ABR measurements were obtained on Day 8. Biochemical measurements were done on Day 0 (pre) and Day 8 (post). The animals were sacrificed on Day 8 for an ultrastructural examination of the inner ear.