Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 29;25(6):1012–1021. doi: 10.1038/s41591-019-0450-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s), under exclusive licence to Springer Nature America, Inc. 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Figure 7 — a, Volcano plot depicting genes that significantly differ between term (n = 41) and preterm (n = 81) cohorts in metagenomics data. Genes mapping to PTB-associated taxa, the L. crispatus cluster and four other common taxa that significantly differ at P_adj < 0.05 (two-sided) with FDR correction are shown in dark red, dark blue and dark green, respectively. b, Comparison of proportional abundance of G. vaginalis in preterm (red) and term (blue) vaginal samples as assayed by 16S rRNA (left), metagenomics (middle) and metatranscriptomics (right), sorted by 16S rRNA (top), metagenomics (middle) and metatranscriptomics (bottom) data. c, Scatter plot of the abundance of G. vaginalis by metagenomics (x axis) and abundance of G. vaginalis by metatranscriptomics (y axis) in pregnant women who delivered term (blue) or preterm (red). Two-sided Wilcoxon’s test of the ratio of the log-transformed proportions (log(metatranscriptomics G. vaginalis proportion)/log(G. vaginalis metagenomics proportion)) showed a significant difference between term and preterm groups (P = 0.01069).