Table A1. Comparison of results from the survey-weighted single chemical analyses and WQS regression of the matrix specific metal mixtures per renal outcome for the urine and blood mixtures (U_mix and B_mix).

The parameter estimate (β) is reported in bold for significant single chemical or WQS mixture effects. The components with the highest weights are reported for mixtures with significant effects (ns: not significant).

		Single chemical regression survey-weighted			WQS regression
Outcome	Matrix	Metal	β_metal (95%CI)	p-value	β_WQS (95%CI)	p-value	Components with highest weight
SUA	Urine	Cd	−0.0006 (−0.007, 0.006)	0.844	−0.0073 (−0.017, 0.002)	0.133	n/a
		Pb	−0.0054 (−0.012, 0.001)	0.115
		Hg	−0.0051 (−0.011,0.001)	0.103
		As	0.0058 (−0.001,0.012)	0.085

	Blood	Cd	−0.0019 (−0.006, 0.003)	0.409	0.0063 (0.000, 0.013)	0.051	Pb, Hg, Cd
		Pb	0.0084 (0.005, 0.012)	<.0001
		Hg	0.0031 (−0.001,0.007)	0.112

BUN	Urine	Cd	−0.0073 (−0.018, 0.003)	0.171	0.0159 (0.005, 0.027 )	0.006	As, Pb
		Pb	0.0040 (−0.005, 0.013)	0.389
		Hg	0.0068 (−0.001,0.015)	0.095
		As	0.0120 (0.000, 0.024)	0.059

	Blood	Cd	0.0021 (−0.004, 0.008)	0.491	0.004 (−0.003, 0.011)	0.265	n/a
		Pb	0.0014 (−0.005, 0.008)	0.657
		Hg	0.0059 (0.000, 0.012)	0.069

eGFR	Urine	Cd	0.0057 (0.000, 0.012)	0.068	0.0137 (0.007, 0.020)	< 0001	Hg Cd As
		Pb	0.0098 (0.004, 0.015)	0.001
		Hg	0.0056 (0.001, 0.010)	0.015
		As	0.0017 (−0.005, 0.008)	0.595

	Blood	Cd	−0.0025 (−0.007, 0.002)	0.248	−0.0032 (−0.009, 0.002)	0.241	n/a
		Pb	−0.0046 (−0.009, 0.000)	0.049
		Hg	−0.0008 (−0.005, 0.004)	0.725

SBP	Urine	Cd	0.0001 (−0.002, 0.003)	0.914	−0.0007 (−0.005, 0.003)	0.713	n/a
		Pb	−0.0009 (−0.004, 0.002)	0.507
		Hg	0.0001 (−0.002, 0.002)	0.925
		As	0.0010 (−0.002, 0.004)	0.495

	Blood	Cd	0.0010 (−0.001,0.003)	0.216	0.001(−0.001,0.003)	0.338	n/a
		Pb	−0.0003 (−0.002, 0.001)	0.712
		Hg	0.0002 (−0.002, 0.002)	0.883

Urine Albumin	Urine	Cd	0.0668 (0.026, 0.107)	0.002	0.0731 (0.024, 0.123)	0 004	Cd Ha Pb
		Pb	0.0305 (0.003, 0.058)	0.030
		Hg	0.0195 (−0.007, 0.053)	0.219
		As	0.0149 (−0.022, 0.052)	0.427

	Blood	Cd	−0.0004 (−0.026, 0.025)	0.974	0.0035 (−0.025, 0.031)	0.807	n/a
		Pb	−0.0072 (−0.028, 0.014)	0.502
		Hg	0.0018 (−0.022, 0.026)	0.881

Table A1. Comparison of results from the survey-weighted single chemical analyses and WQS regression of the matrix specific metal mixtures per renal outcome for the urine and blood mixtures (Umix and Bmix).

Table A1. Comparison of results from the survey-weighted single chemical analyses and WQS regression of the matrix specific metal mixtures per renal outcome for the urine and blood mixtures (U_mix and B_mix).