Table 3.
Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of ocular tests, autoantibodies and LSGB for diagnosis of Sjӧgren’s syndrome
| Sensitivity | Specificity | PPV | NPV | Accuracy | |
|---|---|---|---|---|---|
| Schirmer test <5 mm | 100% | 83.6% | 25% | 100% | 84.5 |
| TBUT <5 seconds | 33.3% | 56.4% | 4% | 93.9% | 55.2 |
| OSS ≥3 | 100% | 90.9% | 37.5% | 100% | 91.4 |
| RF | 0 | 78.2% | 0 | 93.5% | 74.1 |
| ANAs | 0 | 96.4% | 0 | 94.6% | 91.4 |
| Anti-SSA/Ro | 33.3% | 100% | 100% | 96.5% | 96.6 |
| LSGB | 100% | 100% | 100% | 100% | 100 |
Abbreviations: PPV, positive predictive value; NPV, negative predictive value; TBUT, tear-film breakup time; OSS, ocular staining score; RF, rheumatoid factor; ANAs, antinuclear antibodies; LSGB, labial salivary–gland biopsy.