Table 3.
Correlation of base excision repair (BER) system genes expression with overall survival (OS) in gastric cancer patients with HER2 expression status
| BER system | HER 2 status | Cases | HR (95% CI) | P-value |
|---|---|---|---|---|
| UNG | Negative | 298 | 1.42 (1.08−1.88) | 0.013* |
| Positive | 295 | 1.48 (1.13−1.94) | 0.0044* | |
| SMUG1 | Negative | 532 | 1.64 (1.3−2.09) | 3.6e−05* |
| Positive | 344 | 1.47 (1.12−1.93) | 0.0054* | |
| MBD4 | Negative | 532 | 1.29 (1.01−1.66) | 0.041* |
| Positive | 344 | 1.75 (1.31−2.35) | 0.00014* | |
| TDG | Negative | 532 | 2.05 (1.64−2.57) | 2.1e−10* |
| Positive | 344 | 2.44 (1.87−3.18) | 9.9e−12* | |
| OGG1 | Negative | 532 | 2.05 (1.6−2.63) | 7.2e−09* |
| Positive | 344 | 1.68 (1.25−2.27) | 0.00052* | |
| MUTYH | Negative | 532 | 1.46 (1.16−1.85) | 0.0014* |
| Positive | 344 | 1.29 (0.99−1.67) | 0.057 | |
| NEIL1 | Negative | 532 | 2.02 (1.57−2.59) | 2.5e−08* |
| Positive | 344 | 1.62 (1.23−2.14) | 0.00055* |
Note: *P<0.05.
Abbreviations: CI, confidence interval; HR, hazard ratio; HER2, human epidermal growth factor receptor-2; UNG, uracil-DNA glycosylase; SMUG1, single-strand-selective monofunctional uracil-DNA glycosylase 1; MBD4, Methyl-CpG binding domain 4; TDG, thymine DNA glycosylase; OGG1, 8-oxoguanine DNA glycosylase; MUTYH, MutY DNA glycosylase; NEIL1, Nei like DNA glycosylase 1.