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. 2019 Sep 13;12:7501–7512. doi: 10.2147/OTT.S209138

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© 2019 Tong et al.

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Effects of ZFAS1 on PTC cells proliferation and apoptosis.

Notes: (A, C) The cell growth rates were determined by performing CCK-8 and Edu assays. Knockdown of ZFAS1 expression in K-1 cells significantly suppressed cell proliferation, relative to control cells. (B, D) The cell growth rates were detected by performing CCK-8 and Edu assays. Overexpression of ZFAS1 in TPC-1 cells significantly enhanced cell proliferation, relative to control cells. (E) The apoptosis rates of K-1 cells were increased in si-ZFAS1 groups compared with si-NC groups and the apoptosis rates of TPC-1 cells were decreased in pcDNA-ZFAS1 groups compared with Empty vetor groups. (F) The protein levels of BAX and BCL-2 as determined by Western blot analysis in K-1 cells transfected with si-ZFAS1 or si-NC and in TPC-1 cells transfected with pcDNA-ZFAS1 or Empty vetor. *P<0.05, **P<0.01.

Abbreviations: CCK-8, cell counting kit-8; Edu, 5-Ethynyl-2ʹ-deoxyuridine; NC, negative control.