Table S3.
Distribution of comorbidities in patients with tinnitus and their matched controls, stratified by sex: otological and vestibular disorders
| Men (n=53,874) | Women (n=55,909) | |||||||
|---|---|---|---|---|---|---|---|---|
| Tinnitus cases (%) | Tinnitus-free controls (%) | OR crude (95% CI) | OR adjusteda (95% CI) | Tinnitus cases (%) | Tinnitus-free controls (%) | OR crude (95% CI) | OR adjusteda (95% CI) | |
| Sensorineural Hearing Loss | ||||||||
| ≤30 days prior to (includigng) the ID | 330 (0.6) | <5b (0.0) | 166.11 (41.47–665.34) | 171.24 (42.74–686.06) | 288 (0.5) | <5b (0.0) | 148.37 (36.97–595.42) | 153.01 (38.12–614.15) |
| 31 to 360 days prior to the ID | 85 (0.2) | 31 (0.1) | 2.94 (1.93–4.49) | 2.84 (1.86–4.35) | 94 (0.2) | 29 (0.1) | 3.42 (2.24–5.21) | 3.36 (2.20–5.13) |
| >360 days prior to the ID | 565 (1.1) | 380 (0.7) | 1.52 (1.33–1.73) | 1.52 (1.33–1.74) | 577 (1.0) | 321 (0.6) | 1.88 (1.64–2.16) | 1.88 (1.63–2.16) |
| Acute vestibular neuronitis | ||||||||
| ≤30 days prior to (includigng) the ID | 18 (0.0) | <5b (0.0) | 17.98 (2.40–134.54) | 17.90 (2.38–134.45) | 19 (0.0) | 0 (0.0) | NA | NA |
| 31 to 360 days prior to the ID | 23 (0.0) | 5 (0.0) | 4.60 (1.75–12.10) | 3.95 (1.50–10.46) | 45 (0.1) | 22 (0.0) | 2.10 (1.25–3.52) | 1.98 (1.17–3.34) |
| >360 days prior to the ID | 123 (0.2) | 78 (0.1) | 1.58 (1.19–2.09) | 1.49 (1.12–1.99) | 267 (0.5) | 158 (0.3) | 1.70 (1.39–2.07) | 1.69 (1.39–2.07) |
| Otitis media | ||||||||
| ≤30 days prior to (includigng) the ID | 548 (1.0) | 13 (0.0) | 44.05 (25.41–76.36) | 43.55 (25.11–75.54) | 566 (1.0) | 38 (0.1) | 15.74 (11.33–21.86) | 15.76 (11.34–21.91) |
| 31 to 360 days prior to the ID | 784 (1.5) | 201 (0.4) | 4.12 (3.52–4.82) | 4.09 (3.49–4.79) | 969 (1.7) | 288 (0.5) | 3.62 (3.17–4.14) | 3.62 (3.17–4.14) |
| >360 days prior to the ID | 5171 (9.6) | 4391 (8.2) | 1.27 (1.21–1.33) | 1.24 (1.19–1.30) | 6381 (11.4) | 5092 (9.1) | 1.38 (1.32–1.44) | 1.37 (1.32–1.43) |
| Labyrinthitis | ||||||||
| ≤30 days prior to (includigng) the ID | 155 (0.3) | 5 (0.0) | 31.29 (12.84–76.23) | 29.62 (12.14–72.28) | 253 (0.5) | 15 (0.0) | 17.46 (10.37–29.40) | 17.05 (10.11–28.73) |
| 31 to 360 days prior to the ID | 298 (0.6) | 89 (0.2) | 3.47 (2.73–4.40) | 3.43 (2.69–4.36) | 569 (1.0) | 188 (0.3) | 3.16 (2.68–3.74) | 3.07 (2.60–3.64) |
| >360 days prior to the ID | 1453 (2.7) | 992 (1.8) | 1.51 (1.39–1.64) | 1.47 (1.35–1.59) | 2885 (5.2) | 2022 (3.6) | 1.49 (1.40–1.58) | 1.46 (1.38–1.55) |
| Conductive Hearing Loss | ||||||||
| ≤30 days prior to (includigng) the ID | 19 (0.0) | <5b (0.0) | 18.97 (2.54–141.51) | 21.20 (2.81–159.97) | 33 (0.1) | <5b (0.0) | 16.49 (3.96–68.68) | 18.60 (4.45–77.82) |
| 31 to 360 days prior to the ID | 13 (0.0) | <5b (0.0) | 6.50 (1.47–28.80) | 6.95 (1.55–31.13) | 16 (0.0) | <5b (0.0) | 8.00 (1.84–34.79) | 7.62 (1.75–33.25) |
| >360 days prior to the ID | 127 (0.2) | 112 (0.2) | 1.13 (0.88–1.46) | 1.10 (0.85–1.43) | 163 (0.3) | 117 (0.2) | 1.40 (1.10–1.77) | 1.39 (1.09–1.76) |
| Benign positional vertigo | ||||||||
| ≤30 days prior to (includigng) the ID | 146 (0.3) | 12 (0.0) | 12.61 (6.99–22.74) | 11.95 (6.61–21.60) | 316 (0.6) | 25 (0.0) | 13.32 (8.86–20.03) | 13.33 (8.86–20.06) |
| 31 to 360 days prior to the ID | 344 (0.6) | 124 (0.2) | 2.92 (2.37–3.60) | 2.80 (2.27–3.46) | 616 (1.1) | 274 (0.5) | 2.39 (2.07–2.77) | 2.33 (2.01–2.69) |
| >360 days prior to the ID | 1189 (2.2) | 725 (1.4) | 1.70 (1.55–1.87) | 1.65 (1.50–1.82) | 2299 (4.1) | 1569 (2.8) | 1.54 (1.44–1.65) | 1.52 (1.42–1.63) |
| Cerumen | ||||||||
| ≤30 days prior to (includigng) the ID | 2502 (4.6) | 237 (0.4) | 11.83 (10.32–13.56) | 11.58 (10.10–13.29) | 1747 (3.1) | 170 (0.3) | 11.57 (9.84–13.61) | 11.50 (9.77–13.53) |
| 31 to 360 days prior to the ID | 3737 (6.9) | 2037 (3.8) | 2.11 (1.99–2.24) | 2.06 (1.94–2.18) | 2943 (5.3) | 1475 (2.6) | 2.23 (2.09–2.38) | 2.19 (2.05–2.34) |
| >360 days prior to the ID | 7841 (14.6) | 8009 (14.9) | 1.10 (1.06–1.14) | 1.07 (1.04–1.11) | 6861 (12.3) | 6504 (11.6) | 1.16 (1.12–1.21) | 1.15 (1.11–1.20) |
| Otitis externa | ||||||||
| ≤30 days prior to (includigng) the ID | 970 (1.8) | 96 (0.2) | 10.81 (8.74–13.36) | 10.71 (8.65–13.25) | 905 (1.6) | 107 (0.2) | 9.03 (7.38–11.06) | 9.10 (7.43–11.15) |
| 31 to 360 days prior to the ID | 1713 (3.2) | 717 (1.3) | 2.56 (2.34–2.80) | 2.56 (2.34–2.80) | 1862 (3.3) | 789 (1.4) | 2.54 (2.33–2.76) | 2.53 (2.32–2.75) |
| >360 days prior to the ID | 6353 (11.8) | 5585 (10.4) | 1.22 (1.17–1.27) | 1.20 (1.15–1.25) | 6818 (12.2) | 5500 (9.8) | 1.34 (1.29–1.39) | 1.33 (1.28–1.38) |
Notes: aAdjusted for BMI category, smoking status, alcohol consumption. bFor confidentiality reasons, we do not provide the number of patients in categories containing less than five patients.
Abbreviations: CI, confidence interval; ID, index date; NA, not available; OR, odds ratio.