Table S4.
Distribution of comorbidities in patients with tinnitus and their matched controls, stratified by sex: head and neck disorders
| Men (n=53,874) | Women (n=55,909) | |||||||
|---|---|---|---|---|---|---|---|---|
| Tinnitus cases (%) | Tinnitus-free controls (%) | OR crude (95% CI) | OR adjusteda (95% CI) | Tinnitus cases (%) | Tinnitus-free controls (%) | OR crude (95% CI) | OR adjusteda (95% CI) | |
| Tension-type headache | ||||||||
| ≤30 days prior to (includigng) the ID | 38 (0.1) | 0 (0.0) | NA | NA | 66 (0.1) | 9 (0.0) | 7.47 (3.72–14.99) | 7.55 (3.76–15.18) |
| 31 to 360 days prior to the ID | 117 (0.2) | 48 (0.1) | 2.47 (1.77–3.46) | 2.38 (1.70–3.35) | 242 (0.4) | 97 (0.2) | 2.56 (2.02–3.24) | 2.57 (2.03–3.26) |
| >360 days prior to the ID | 1143 (2.1) | 708 (1.3) | 1.64 (1.49–1.81) | 1.57 (1.43–1.73) | 2188 (3.9) | 1468 (2.6) | 1.54 (1.44–1.65) | 1.52 (1.42–1.63) |
| Concussion | ||||||||
| ≤30 days prior to (includigng) the ID | 14 (0.0) | <5b (0.0) | 14.00 (1.84–106.41) | 13.36 (1.74–102.45) | 11 (0.0) | <5b (0.0) | 5.50 (1.22–24.80) | 5.98 (1.32–27.08) |
| 31 to 360 days prior to the ID | 15 (0.0) | 7 (0.0) | 2.14 (0.87–5.26) | 2.31 (0.93–5.75) | 24 (0.0) | 12 (0.0) | 2.00 (1.00–4.00) | 2.00 (1.00–4.01) |
| >360 days prior to the ID | 332 (0.6) | 324 (0.6) | 1.03 (0.88–1.20) | 1.02 (0.88–1.20) | 207 (0.4) | 173 (0.3) | 1.20 (0.98–1.47) | 1.21 (0.99–1.49) |
| Temporomandibular joint disorders | ||||||||
| ≤30 days prior to (includigng) the ID | 38 (0.1) | 7 (0.0) | 5.43 (2.42–12.15) | 5.27 (2.34–11.85) | 77 (0.1) | 10 (0.0) | 7.81 (4.05–15.10) | 7.59 (3.92–14.70) |
| 31 to 360 days prior to the ID | 106 (0.2) | 38 (0.1) | 2.80 (1.93–4.06) | 2.73 (1.88–3.97) | 202 (0.4) | 106 (0.2) | 1.93 (1.53–2.45) | 1.86 (1.47–2.36) |
| >360 days prior to the ID | 696 (1.3) | 413 (0.8) | 1.70 (1.51–1.93) | 1.64 (1.44–1.85) | 1627 (2.9) | 1088 (2.0) | 1.53 (1.41–1.65) | 1.50 (1.39–1.62) |
| Whiplash | ||||||||
| ≤30 days prior to (includigng) the ID | 44 (0.1) | 7 (0.0) | 6.44 (2.90–14.30) | 5.77 (2.59–12.86) | 42 (0.1) | 8 (0.0) | 5.27 (2.47–11.22) | 5.12 (2.40–10.92) |
| 31 to 360 days prior to the ID | 160 (0.3) | 112 (0.2) | 1.45 (1.13–1.84) | 1.41 (1.10–1.81) | 185 (0.3) | 120 (0.2) | 1.56 (1.24–1.97) | 1.54 (1.22–1.94) |
| >360 days prior to the ID | 2144 (4.0) | 1724 (3.2) | 1.26 (1.18–1.35) | 1.25 (1.17–1.33) | 2373 (4.2) | 2054 (3.7) | 1.17 (1.10–1.25) | 1.16 (1.09–1.23) |
| Cervicalgia | ||||||||
| ≤30 days prior to (includigng) the ID | 425 (0.8) | 81 (0.2) | 5.57 (4.39–7.07) | 5.41 (4.26–6.88) | 560 (1.0) | 129 (0.2) | 4.90 (4.03–5.95) | 4.80 (3.94–5.83) |
| 31 to 360 days prior to the ID | 1184 (2.2) | 674 (1.3) | 1.90 (1.72–2.09) | 1.81 (1.64–2.00) | 1816 (3.3) | 1066 (1.9) | 1.88 (1.74–2.03) | 1.83 (1.69–1.98) |
| >360 days prior to the ID | 7533 (14.0) | 5411 (10.0) | 1.53 (1.47–1.59) | 1.49 (1.43–1.55) | 10,542 (18.9) | 7988 (14.3) | 1.48 (1.43–1.53) | 1.46 (1.41–1.51) |
| Migraine | ||||||||
| ≤30 days prior to (includigng) the ID | 103 (0.2) | 17 (0.0) | 6.16 (3.69–10.30) | 5.73 (3.42–9.60) | 243 (0.4) | 63 (0.1) | 4.09 (3.10–5.39) | 3.98 (3.01–5.26) |
| 31 to 360 days prior to the ID | 246 (0.5) | 134 (0.3) | 1.87 (1.51–2.31) | 1.77 (1.43–2.19) | 799 (1.4) | 469 (0.8) | 1.81 (1.62–2.04) | 1.76 (1.57–1.98) |
| >360 days prior to the ID | 2821 (5.2) | 1988 (3.7) | 1.45 (1.37–1.54) | 1.41 (1.33–1.49) | 6698 (12.0) | 5172 (9.3) | 1.37 (1.32–1.42) | 1.35 (1.30–1.40) |
| Cranial nerve disorders | ||||||||
| ≤30 days prior to (includigng) the ID | 33 (0.1) | 10 (0.0) | 3.30 (1.63–6.70) | 3.43 (1.68–6.99) | 57 (0.1) | 11 (0.0) | 5.23 (2.74–9.98) | 5.14 (2.69–9.83) |
| 31 to 360 days prior to the ID | 122 (0.2) | 53 (0.1) | 2.36 (1.70– 3.28) | 2.26 (1.62–3.14) | 220 (0.4) | 124 (0.2) | 1.78 (1.43–2.23) | 1.75 (1.40–2.19) |
| >360 days prior to the ID | 874 (1.6) | 722 (1.3) | 1.22 (1.10– 1.35) | 1.21 (1.09–1.33) | 1412 (2.5) | 1050 (1.9) | 1.36 (1.26–1.48) | 1.37 (1.26–1.48) |
Notes: aAdjusted for BMI category, smoking status, alcohol consumption. bFor confidentiality reasons, we do not provide the number of patients in categories containing less than five patients.
Abbreviations: CI, confidence interval; ID, index date; NA, not available; OR, odds ratio.