Figure 1.

UBE2T is upregulated in HCC and correlates with clinical features. (A) UBE2T expression was markedly increased in 5 of 6 paired HCC tissues (T) compared with matched non-tumor tissues (N). Total protein as a loading control by staining the membranes with Coomassie brilliant blue. (B) UBE2T expression in human hepatoma cell lines using Western blot. Fetal hepatocyte (FH) cells served as a control. (C) Gray scale of UBE2T expression detected by Western blot in human hepatoma cell lines and FH (n=3). (D) UBE2T mRNA was upregulated in Wurmbach liver from the oncomine database. (E) The correlation of UBE2T and HCC pathological grade in Wurmbach cohort. (F) The correlation of UBE2T and HCC vascular invasion in Wurmbach cohort. (G) High expression of UBE2T was correlated with poor overall survival compared with low expression group in TCGA-LIHC cohort.

Abbreviations: HCC, hepatocellular carcinoma; UBE2T, ubiquitin-conjugating enzyme E2T; GAPDH, glyceraldehyde 3-phosphate dehydrogenase.