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. 2019 Sep 13;11:8359–8370. doi: 10.2147/CMAR.S202631

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© 2019 Liu et al.

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UBE2T regulates G2-to-M transition by modulating cyclin B1 and CDK1. (A) Immunoblot assay for expression of cell-cycle-associated factors in UBE2T-KD (SMCC-7721) and UBE2T-OE (SK-Hep1) cell lines. (B) The quantitative expression ratio of protein expression of UBE2T-KD and UBE2T-OE relative to control group. GAPDH was used as internal control, and the experiment was repeated at least three times independently. UBE2T-KD: UBE2T stable interference cells; UBE2T-OE: UBE2T stable overexpression cells. (C) There was a significant positive correlation between UBE2T and CCNB1 expression, Spearman correlation coefficient R=0.88, P=7.3e-139. (D) UBE2T was significantly positively correlated with CDK1 expression, Spearman correlation coefficient R=0.92, P=1.7e-169. **P<0.01, ***P<0.001.

Abbreviations: UBE2T, ubiquitin-conjugating enzyme E2T; UBE2T-KD, UBE2T knockdown; UBE2T-OE, UBE2T overexpression; KD-control, control cells transfected with the control vector; OE-control, control cells transfected the empty vector; CDK1, cyclin-dependent kinase 1.