Table.

cAMP Permeability of Cx43, Cx46, and Cx50 Channels

Parameter	Cx43	Cx46	Cx50
ΔI/Δt vs. Gj slope (s−1/nS) ± SE	2.7 ± 0.3 × 10−3	3.7 ± 0.3 × 10−4	3.9 ± 3 × 10−5
Unitary conductance (pS)	55	146	200
cAMP flux (molecules/channel/sec)	6095 (5880*)	1220	176
Relative permeability (cAMP/K+)	0.18	0.014	0.0015
Single channel permeability (cm3/s)	2.0 × 10−14	4.1 × 10−15	5.8 × 10−16

^*Previously calculated value for Cx43 from Kanaporis et al.¹⁵