Table 1.
Summary information for all groups from which recordings were made
| sEPSCs | #Events | #Cells | #Animals | Amplitude (pA), all events |
Amplitude (pA), by cells |
Frequency (Hz), all events |
Frequency (Hz), by cells |
Charge transfer (pA*ms) |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Median ± SD | Range | Average of medians ± SEM | Range | Median ± SD | Range | Average of medians ± SEM | Range | Average of sums ± SEM | Range | ||||
| EB sham | 1195 | 10 | 6 | 5.8 ± 5.1 | 2.7–92.9 | 5.8 ± 0.3 | 4.6–7.9 | 0.8 ± 14.2 | 0.03–311.5 | 0.7 ± 0.1 | 0.2–1.8 | 1621 ± 256.2 | 224.7–2626 |
| EB SE | 1386 | 5 | 4 | 7.0 ± 5.6 | 2.8–61.6 | 6.4 ± 0.5 | 5.3–8.0 | 2.1 ± 24.7 | 0.03–285.7 | 1.5 ± 0.4 | 0.5–2.8 | 5866 ± 2323 | 746.1–10,948 |
| AB sham | 924 | 9 | 5 | 5.7 ± 2.8 | 2.9–32.4 | 5.5 ± 0.3 | 4.1–7.1 | 0.8 ± 17.2 | 0.03–396.8 | 0.6 ± 0.2 | 0.9–1.3 | 1268 ± 393.1 | 47.5–3712 |
| AB norm | 1655 | 16 | 9 | 6.1 ± 3.1 | 2.1–39.5 | 6.1 ± 0.3 | 4.4–8.4 | 1.0 ± 44.7 | 0.02–1235.0 | 0.9 ± 0.2 | 0.1–2.4 | 1335 ± 318.9 | 302.5–5090 |
| AB ab | 16,088 | 11 | 7 | 9.4 ± 6.5 | 2.3–87.8 | 9.1 ± 1.2 | 4.6–19.0 | 21.9 ± 83.0 | 0.05–8333.0 | 9.0 ± 3.7 | 0.8–31.5 | 32,991 ± 13,670 | 925.1–125,810 |
| AB ect | 12,529 | 5 | 3 | 9.6 ± 6.2 | 2.3–87.8 | 11.7 ± 1.9 | 8.3–19.0 | 27.1 ± 91.5 | 0.14–8333.0 | 13.8 ± 6.8 | 1.1–31.5 | 54,574 ± 24,274 | 4333–125,810 |
| AB HBD | 3559 | 6 | 5 | 8.3 ± 7.5 | 2.3–57.2 | 7.0 ± 1.0 | 4.6–9.6 | 6.2 ± 28.6 | 0.05–357.1 | 4.2 ± 1.5 | 0.8–4.5 | 11,409 ± 4330 | 925.1–23,451 |
| sIPSCs | #Events | #Cells | #Animals | Amplitude (pA), all events |
Amplitude (pA), by cells |
Frequency (Hz), all events |
Frequency (Hz), by cells |
Charge transfer (pA*ms) |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Median ± SD | Range | Average of medians ± SEM | Range | Median ± SD | Range | Average of medians ± SEM | Range | Average of sums ± SEM | Range | ||||
| EB sham | 5843 | 11 | 4 | 39.8 ± 60.1 | 5.8–728.3 | 48.3 ± 5.9 | 15.8–55.1 | 5.3 ± 53.2 | 0.03–924.2 | 3.8 ± 0.8 | 1.0–8.7 | 142,108 ± 41,278 | 24,813–416,224 |
| EB SE | 1751 | 7 | 3 | 58.0 ± 65.5 | 12.2–679.4 | 52.4 ± 5.4 | 25.3–50.4 | 2.1 ± 33.2 | 0.04–666.7 | 1.8 ± 0.6 | 0.5–4.4 | 61,430 ± 18,118 | 21,096–155,587 |
| AB sham | 4232 | 8 | 6 | 50.0 ± 53.5 | 7.5–800.4 | 48.1 ± 8.1 | 13.9–47.8 | 4.3 ± 44.0 | 0.06–1041.0 | 3.6 ± 0.8 | 0.9–7.4 | 128,920 ± 43,152 | 26,064–363,675 |
| AB norm | 16,461 | 14 | 6 | 39.7 ± 63.9 | 3.9–940.9 | 41.2 ± 8.9 | 7.1–134.9 | 14.8 ± 49.8 | 0.03–695.4 | 7.0 ± 2.2 | 0.3–23.4 | 396,385 ± 128,190 | 1161–1,712,463 |
| AB ab | 19,277 | 13 | 7 | 48.1 ± 75.7 | 3.3–889.8 | 43.9 ± 6.1 | 10.0–55.5 | 22.3 ± 65.4 | 0.03–3610.0 | 12.7 ± 4.9 | 0.5–55.9 | 628,383 ± 299,644 | 5308–3,873,926 |
| AB ect | 6606 | 6 | 5 | 29.5 ± 33.5 | 4.7–594.6 | 27.3 ± 5.5 | 10.0–25.1 | 13.4 ± 67.9 | 0.03–680.7 | 13.3 ± 8.7 | 0.7–55.9 | 295,332 ± 191,874 | 5308–1,241,813 |
| AB HBD | 12,671 | 7 | 5 | 62.4 ± 86.0 | 3.3–889.8 | 58.1 ± 6.5 | 23.9–55.5 | 26.5 ± 64.1 | 0.05–3610.0 | 12.3 ± 5.7 | 0.5–42.0 | 913,856 ± 527,036 | 28,266–3,873,926 |
The numbers of animals, cells, and events recorded along with summary information for each variable analyzed are shown. In general, median values (instead of means) were used because they better represent non-normally distributed data. For “all events” columns, calculations were performed with all individual events from all recordings within each group considered together (n = number of events shown in the left column). For “by cell” columns, calculations were first performed only on events recorded from individual cells; then data from each cell was tabulated to generate measures for each group (n = number of cells). In this case, error was propagated mathematically from the variance of events for each individual recording. Birthdate = EB (early born) or AB (adult born); treatment = SE (status epilepticus) or sham control; location = ect (ectopic) or norm (normotopic). HBD denotes cells that maintained hilar basal dendrites.