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. Author manuscript; available in PMC: 2019 Sep 18.
Published in final edited form as: Cell Rep. 2019 Aug 20;28(8):2080–2095.e6. doi: 10.1016/j.celrep.2019.07.069

Figure 5. Diverse Mutations at Certain NBD1 Sites Potentiate Hsp104.

Figure 5.

(A) Hsp104 variants mutated at the I187 position and controls were transformed into W303aΔhsp104 yeast harboring α-syn (left), TDP-43 (center), or FUS (right) genes. Strains were serially diluted 5-fold and spotted in duplicate onto glucose (non-inducing) or galactose (inducing) media.

(B–D) Hsp104 variants mutated at the I230 position (B), Q347 position (C), or E360 position (D) were assessed as in (A).

See also Figures S3.