Skip to main content
. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jul 23;1864(11):1669–1680. doi: 10.1016/j.bbalip.2019.07.009

Figure 10.

Figure 10.

Effects of DHA or RvD2 treatment and 12/15-LO inhibition on renal TNF-α and ICAM-1 mRNA expression levels in LPS injected mice. DHA or RvD2 administration significantly reduced the elevation in renal TNF-α and ICAM-1 mRNA expression levels in LPS injected WT mice. Knocking-out of 12/15-LO prevented the elevation in renal TNF-α and ICAM-1 compared to LPS injected WT mice and these effects were not further decreased with DHA treatment in LPS injected 12/15-LO KO mice (n=6–8; *P<0.05 vs. control WT or 12/15-LO KO group, #P<0.05 vs. WT LPS group).