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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jul 23;1864(11):1669–1680. doi: 10.1016/j.bbalip.2019.07.009

Figure 2.

Figure 2.

Effects of pharmacological inhibition of 12/15-LO with baicalein or genetic manipulation of 12/15-LO using 12/15-LO KO mice on LPS-induced changes in renal injury markers; creatinine clearance (A) and microalbuminuria (B). LPS injection significantly decreased creatinine clearance and increased albuminuria. baicalein treatment increased creatinine clearance and reduced albumin excretion levels in LPS injected WT mice. 12/15 LO inhibition prevented the significant decrease in creatinine clearance and the increase in albuminuria in LPS injected 12/15-LO KO mice (n=6–8, *P<0.05 vs. control group and #P<0.05 vs. LPS group).