Figure 6.
Effects of baicalein on LPS-induced increase in 12/15-LO mRNA expression (A) and decrease in the anti-inflammatory IL-10 mRNA expression (B). Baicalein improved renal IL-10 mRNA expression without a significantly decrease in 12/15-LO expression in the LPS injected mice. Knocking-out of 12/15-LO prevented the increase in 12/15-LO or the decrease in IL-10 in 12/15-LO KO mice (n=6–8; *P<0.05 vs. control group and #P<0.05 vs. WT LPS group).