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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2019 Jul 27;1865(11):165516. doi: 10.1016/j.bbadis.2019.07.010

Figure 1. Schematic representation of GALT-deficiency induced Subfertility phenotype in the mouse model.

Figure 1.

Dietary and Endogenously produced galactose is phosphorylated to galactose- 1 phosphate (gal-1P) by galactokinase (GALK1). In the presence of galactose–1 phosphate uridylyltransferase (GALT), gal-1P reacts with UDP- glucose to form UDP-galactose and glucose- 1 phosphate. Gal-1P accumulation causes ER stress and ovarian dysfunction. Salubrinal inhibits eIF2α dephophorylation, potentially ameliorating galactosemic stress, and normalizes the ovarian functions.