Table 1:

Multivariate analyses of the three imaging parameter (fat fraction, shear stiffness, and loss modulus) effects for the prediction of several key histologic features in the training cohort of 64 mice. Effects are reported as parameter estimates. 95% confidence intervals (CI) and p-values (bold if significant). All observed significant effects show positive correlations between the imaging predictors and the histological findings.

Multivariate Analysis of Imaging Biomarkers		Histological Features in NAFLD Progression
		Steatosis	Inflammation		Ballooning	Fibrosis
			Lobular	Portal
Fat Fraction	Estimate 95% CI	8.08 [7.22, 8.93]	1.15 [−0.13, 2.43]	0.12 [−0.46, 0.69]	0.84 [0.08, 1.59]	1.55 [0.17, 2.93]
	P-value	<0.0001	0.07	0.69	0.03	0.03
Loss Modulus	Estimate 95% CI	5.06 [−5.35, 15.47]	19.95 [4.40, 35.50]	6.59 [−0.39, 13.57]	7.14 [−2.01, 16.29]	19.76 [2.98, 36.55]
	P-value	0.34	0.01	0.06	0.12	0.02
Shear Stiffness	Estimate 95% CI	2.02 [0.93, 3.11]	4.29 [2.66, 5.92]	1.50 [0.77, 2.24]	3.00 [2.04, 3.96]	6.35 [4.59, 8.11]
	P-value	<0.001	<0.0001	0.0001	<0.0001	<0.0001