FIG 4.

Strains selected under high amoxicillin/low clavulanate adapt to their environment better and are more greatly affected by the amoxicillin proportion of the drug environment. Optical density after 22-h growth is shown for strains adapted to each of five amoxicillin ratios, at different dose strengths, and then assayed at different amoxicillin proportions (but the same dose strength). (a to e) Lines adapted to amoxicillin proportions of 0.04, 0.25, 0.57, 0.84 and 0.98, respectively (highlighted by the gray region). Lines are the fits of a mixed-effects model detailed in the text, with dashed lines showing the fits for the individual evolved lines.