FIG 5.

Strains selected at high dose strengths adapt to their environment better and are less strongly affected by increases in the drug dose. Optical density after 22-h growth is shown for strains adapted to (a) low, (b) medium, and (c) high dose strengths and assayed at all dose strengths (but same amoxicillin proportion). Lines are the fits of a mixed-effects model detailed in the text, with dashed lines showing the fits for the individual evolved lines. The gray areas indicate the dose strength the lines were selected with.