TABLE 1.

Concentrations of amoxicillin and clavulanate used for the drug environments used in this paper^a

Amoxicillin proportion	Drug component	Drug concentration (μg/ml) at the following dose strength:
		Low [0]	Medium [1]	High [2]
0.04	Amoxicillin	0.595	0.723	0.850
	Clavulanate	19.0	23.1	27.2
0.25	Amoxicillin	1.47	1.79	2.10
	Clavulanate	5.89	7.14	8.40
0.57	Amoxicillin	2.59	3.15	3.70
	Clavulanate	2.59	3.15	3.70
0.84	Amoxicillin	5.04	6.12	7.20
	Clavulanate	1.26	1.53	1.80
0.98	Amoxicillin	12.6	15.3	18.0
	Clavulanate	0.394	0.478	0.523

^aFor each of the drug ratios (defined by the amoxicillin proportion), there are three drug doses corresponding to increasing strength of selection. Amoxicillin proportion is calculated as the proportion of amoxicillin in the combination, where both concentrations are relative to their maximum concentrations (maximum amoxicillin concentration [a_max] of 30 and maximum clavulanate concentration [b_max] of 40). The concentrations (in micrograms per milliliter) at the different dose strengths are 70%, 85%, and 100% of the high-dose strength (shown in boldface type). The numbers in brackets (0, 1, and 2) show how dose strength was coded in the statistical models.