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Phospho-tau expression patterns show minimal variation with gestational age during the second trimester. Positive staining for S214 in the molecular layer remains essentially invariant from 14 PCW to 24 PCW, with gradual decrease in staining intensity by 37 PCW. Top row shows negative (normal adult brain) and positive (PSP, AD) controls. PSP, progressive supranuclear palsy; AD, Alzheimer disease; PCW, postconceptional weeks; ml, molecular layer; cp, cortical plate. Black bar = 50 μm.
