Figure 5.

Model for the Assembly and Maturation of Pre-60S Particles in Arabidopsis.

The picture illustrates the so-called yeast 60S particle in the nucleolus (Ssf1 and Nsa), nucleoplasm (Arx1/Rsa4, Rix1/Rea1, and Arx1/Nmd3/Mex67), and cytoplasm (Lsg1). Arabidopsis homologs of yeast processome factors and subcomplexes (blue and violet), protein export (red), and GTPase (orange) activities are represented. Those not yet identified are shown in gray. Plant GTS1, orthologous to human WDR39, is represented in dark green. The figure was adapted and drawn from simplified models of the assembly steps of the 60S particles in yeast (Shchepachev and Tollervey, 2016; Kressler et al., 2017). Accession numbers for all the Arabidopsis factors are provided in Supplemental Data Set 4.