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. 2019 Sep 18;9:13519. doi: 10.1038/s41598-019-50077-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Schematic of a typical DLS instrument, configured to detect backscattered light from the dispersed sample. (b) Replicate time averaged particle size distributions for a protein sample, showing the intermittent appearance of a large size component which also coincides with a perturbation to the position of the primary peak. (c–e) Analysis process of a DLS measurement- Light scattering intensity (c) showing a spike in the signal due to the appearance of an aggregate at t > 8 s, which can which can degrade the measured correlation function (g₂-1) (d) and the accuracy of the intensity weighted particle size distribution (e).