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. 2019 Sep 18;9:235. doi: 10.1038/s41398-019-0569-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Two-way ANOVA with Tukey post hoc test was performed (males (M): N.Ch. Adnp^+/+ N = 29; N.Ch. Adnp^+/− N = 24; +Ch. Adnp^+/+ N = 7; +Ch. Adnp^+/− N = 4; +Ch. Adnp^+/+ PACAP N = 9; +Ch. Adnp^+/− PACAP N = 4; females (F): N.Ch. Adnp^+/+ N = 7; N.Ch. Adnp^+/− N = 6; +Ch. Adnp^+/+ N = 9; +Ch. Adnp^+/− N = 7; +Ch. Adnp^+/+ PACAP N = 8; +Ch. Adnp^+/− PACAP N = 7). a In stress-challenged male mice, main genotype (F(1,20) = 4.444, p = 0.048) and interaction (F(1,20) = 4.628, p = 0.044) effects were found, with significant differences between PACAP- and vehicle-treated Adnp^+/− mice (*p < 0.05), and Adnp^+/+ vs. Adnp^+/− mice (**p < 0.01). In vehicle-treated male mice, main genotype (F(1,60) = 12.085, p < 0.001) and challenge (F(1,60) = 4.873, p = 0.031) effects were found, with significant differences between non-challenged Adnp^+/+ and Adnp^+/− mice (*p < 0.05), and challenged vs. non-challenged Adnp^+/− mice (*p < 0.05). b In stress-challenged female mice, main treatment effect was found (F(1,27) = 4.392, p = 0.046), with a significant difference between PACAP- and vehicle-treated Adnp^+/− mice (**p < 0.01). In vehicle-treated female mice, main challenge effect was found (F(1,25) = 4.419, p = 0.046), with a significant difference between stress-challenged and non-stressed Adnp^+/− mice (*p < 0.05)