Fig. 1. Clustering of disorders based on alterations of 38 inflammation-related factors identified from sufficiently powered meta-analyses in blood samples.

Red cells are the increased changes in disorders (effect size (ES) > 0, P < 0.05 and power > 0.8); blue cells are the decreased changes in disorders (ES < 0, P < 0.05 and power > 0.8); yellow cells are the not significant changes in disorders (P > 0.05, power > 0.8); white cells represent missing data, either not being studied or only an underpowered study in the meta-analyses; orange cells with question marks are those with inconsistent results. “*” in the cells indicates that the significant changes are found in more than two meta-analyses. MDD, ASD, PTSD, suicide, SD, BD and SCZ have 16, 7, 3, 5, 2, 8 and 7 IRF changes, respectively