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. 2019 Sep 18;10:4241. doi: 10.1038/s41467-019-12017-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Pathophysiological parameters measured in the lungs during PbAluc-infection in C57BL/6 mice. a Peripheral parasitemia levels and b survival curve of PbAluc-infected mice (n = 9). The boxed area indicates the experimental cerebral malaria (ECM) phase. c Ratio of lung edema (wet-to-dry weight ratio) at 7 days post infection (dpi) in infected (n = 7) and naive C57BL/6 (n = 3) mice. d Ratio of in vivo lung vascular leakage measured by Tracer-653 dye at 3–7 dpi (n = 10). e Ex vivo quantification of parasite biomass in the lungs based on luciferase activity of luciferase-tagged parasite after perfusion at 3 (n = 5) 4 (n = 4), 5 (n = 4), 6 (n = 5) and 7 dpi (n = 4). The data shown are representative of two independent experiments. f Ratio of in vivo lung vascular leakage assessed in mice with non-cerebral malaria (NCM) (n = 9) and with experimental cerebral malaria (ECM) (n = 24). The black dashed line at y = 1 in (d–f) represents the ratio of the tracer reading from naive C57BL/6 mice (n = 3). g MRI images of naïve C57BL/6 (n = 4) and PbAluc-infected mice (n = 5) taken consecutively from 4–7 dpi. Yellow arrows show edema (left hand side images). Edema quantification based on manual segmentation/volume calculation (right hand side graph). The data represent the mean ± SD; *p < 0.05 by Mann–Whitney test (c); *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 by ANOVA with Bonferroni’s post-test (d–e, g). Figure e, “#” represents statistical significance compared to 3 dpi; ^a,b,cp < 0.0001; Figure g, represents statistical significance compared to 4 dpi (p < 0.05); “#” represents statistical significance compared to 5 dpi (***p < 0.001)