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. 2019 Sep 18;9:13513. doi: 10.1038/s41598-019-49824-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Alterations in expression levels of GABA_A receptor α1 subunit in dorsal and ventral hippocampal subregions following stress exposure and environmental enrichment. (A) Dorsal hippocampus. In the dDG, expression levels of GABA_A α1 were increased in all groups compared to control rats. In the dCA1, α1 expression levels were increased only in J + A rats compared to control. (B) Ventral hippocampus. In the vDG, both J + A and J + A + EE rats showed higher expression levels of GABA_A receptor α1 compared to control and J + EE + A rats. In the vCA1, while J + A rats showed higher α1 expression levels compared to all other groups, J + A + EE rats showed increased α1 expression compared to J + EE + A rats. All values are % density of mean control (mean ± SEM). Significant difference from control: *p < 0.05, **p < 0.01, ***p < 0.001. Significant difference from J + EE + A: ^$p < 0.05, ^$$p < 0.01, ^$$$p < 0.001. Significant difference from J + A + EE: # p < 0.05. Sample blots are line blots from the same gel.