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. 2019 Sep 18;9:13513. doi: 10.1038/s41598-019-49824-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increased expression levels of GABA_A receptor α1 subunit in the ventral hippocampal subregions of stress resilient animals. (A) Dorsal hippocampus. No significant interactions of stress-exposure group x behavioral profile were observed in either the dDG or dCA1. (B) Ventral hippocampus. For GABA_A receptor α1 in the vDG, a significant interaction of stress-exposure group x behavioral profile was observed. An increased expression of GABA_A receptor α1 was observed in unaffected rats of both J + A and J + A + EE groups, compared to unaffected rats from the control and J + EE + A groups. Direct comparison also revealed an increase in GABA_A receptor α1 levels in unaffected rats compared to affected rats within the J + A group. A similar expression pattern was observed for GABA_A receptor α1 in the vCA1 of unaffected rats in both J + A and J + A + EE groups, compared to unaffected rats from the control and J + EE + A groups. Here, direct comparison revealed an increase in GABA_A receptor α1 levels in unaffected rats compared to affected rats in both J + A and the J + A + EE groups. All values are % density of mean control (mean ± SEM). Significantly different from unaffected control: **p < 0.01, ***p < 0.001. Significant difference from unaffected J + EE + A: ^$$p < 0.01, ^$$$p < 0.001. Significant difference unaffected vs. affected rats: ⁺p < 0.05, ⁺⁺p < 0.01, ⁺⁺⁺p < 0.001.