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. 2019 Sep 18;10(10):687. doi: 10.1038/s41419-019-1917-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a The representative mouse and tumors of the xenograft mouse modes in DMSO, SB239063 (10 mg/kg), dynasore (10 mg/kg) and combination-treated groups. b Tumor volumes were measured every day since day 3 after model establishment (day 0), and drugs administration were initiated at day 4 (red arrow). c Tumor samples of four xenograft mice groups were under H&E staining (Scare bar: 40 μm). d, e Xenograft tumor tissues were subjected to IHC staining by using Ki67 antibody (Scare bar: 40 μm). *p < 0.05 and **p < 0.01 vs. DMSO group