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. 2019 Sep 12;10:2191. doi: 10.3389/fimmu.2019.02191

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Copyright © 2019 Li, Yan, Liu, Huang, Zhang, Kirschning, Xu, Lang, Dittmer, Zhang and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enhancement of the effector function of CD8+ T cells mediated by TLR7 agonists is MyD88-dependent. Purified CD8+ T cells from WT, TRIF^−/−, MyD88^−/−, and TRIF/MyD88^−/− mice were stimulated in plates with bound αCD3 antibody (5 μg/mL) alone or with R848 (10 μg/mL) for 24 h. CD25, CD44, and CD69 (A), T-bet and Eomes (B) expression in CD8+ T cells were analyzed by flow cytometry. (C) Cytokines production including IFN-γ and IL-2 was detected by specific ELISAs. Data are representative of two independent experiments. All data are presented as mean ± SD. The statistical relevance was determined by Two-way ANOVA: *p < 0.05; **p < 0.01; ***p < 0.001; ns, not significant.