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. 2019 Sep 12;10:1173. doi: 10.3389/fphys.2019.01173

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Copyright © 2019 Man, Li and Xia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Crosstalk between endothelial SIRT1 and eNOS in mediating endothelial function. Schematic presentation of the current idea on the reciprocal regulation of SIRT1 and eNOS. Resveratrol activates both SIRT1 and eNOS, whereas FOXO1 and FOXO3a are involved in the resveratrol induced eNOS transcriptional activation, based on the published literature (Xia et al., 2013). Cilostazol increases NO production by stimulating eNOS serine 1177 phosphorylation mediated by cAMP/PKA- and PI3K/Akt-dependent pathways. NO, nitric oxide; FOXO, forkhead box O; SMC, smooth muscle cells. KLF2, Krüppel-like Factor 2.