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. 2019 Sep 12;7:221. doi: 10.3389/fbioe.2019.00221

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Copyright © 2019 Sharifi, Firoozabadi and Firoozbakhsh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Validation and Grid study for evaluation of the presented code used in this study. (A) Oxygen concentration profile along the spheroid diameter for different mesh numbers. (B) Comparison of computed results of the fluid velocity inside the channel to those reported by Tourlomousis and Chang (2016b). (C) Comparison of the predicted metabolites participating in the urea cycle with the results given by Kuchel et al. (1977) (D) Oxygen concentrations are compared with the experimental data obtained by Murphy et al. (2017) for three different spheroid sizes.