Figure 1.

Frequencies of CD4⁺T cells and CD4⁺T cell subsets in healthy controls (HC) and GPA patients in remission (GPA). Representative FACS plots of sorted CD4⁺T cell subsets (A). CD4⁺T cell frequencies were lower in GPA than in HC (B). Within the CD4⁺T cell population, no differences were observed in naïve T (T_NAVE) cells (CD4⁺CD45RO⁻CCR7⁻) (C), whereas the _MTreg (CD4⁺CD127⁻CD25^HighCD45RO⁺) frequency was higher in GPA than in HC (D). A significantly higher frequency of CD4⁺T effector memory (T_EM) cells (CD4⁺CD45RO⁺CCR7⁻) was observed in GPA than in HC (E). **P = 0.01–0.001, ***P ≤ 0.001.