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. 2019 Sep 12;10:2170. doi: 10.3389/fimmu.2019.02170

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Copyright © 2019 Dekkema, Bijma, Jellema, Van Den Berg, Kroesen, Stegeman, Heeringa, Abdulahad and Sanders.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-142-3p is overexpressed in _MTregs from GPA patients in remission and is differentially regulated in CD4⁺T cell subsets. miR-142-3p levels were significantly higher in _MTregs from GPA patients (GPA) than in those from healthy controls (HC) (A). miR-142-3p levels were significantly lower in _MTregs than in _NTregs (B) and in CD4⁺T_NAVE and CD4⁺T_EM cells from HC (circles) and GPA patients (squares) (C). Stimulation of _MTregs and _NTregs with anti-CD3-CD28 Dynabeads led to significantly lower miR-142-3p levels over time (n = 5) (D). *P = 0.05–0.01, **P = 0.01–0.001.