Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 12;10:2170. doi: 10.3389/fimmu.2019.02170

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Dekkema, Bijma, Jellema, Van Den Berg, Kroesen, Stegeman, Heeringa, Abdulahad and Sanders.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Proposed model of miR-142-3p, which targets the adenylyl cyclase 9/cAMP-mediated suppression of Tregs. We propose that miR-142-3p overexpression in GPA patients reduces ADCY9 levels, which leads to less conversion of ATP to cAMP upon stimulation. cAMP can be transferred to effector cells via a Gap junction (GJ). Upon transfection, cAMP levels in effector cells increase, which induces metabolic disruption and inhibits IL-2 production and cell proliferation. Increased miR-142-3p levels therefore decrease Treg function.