TABLE 3.
Association of metabolite changes to HAM-D17 changes from baseline to week 12 upon exposure to CBT, by univariate models.
| Metabolite | Pearson correlation | Linear mixed model | Module-membership | ||
| CorrCoeff | p-value | CoeffEstimate | p-value | ||
| α-aminoadipic acid | –0.5164 | 0.0069 | −0.2(−0.3,−0.1) | 0.0093 | Purple |
| Isoleucine | –0.3372 | 0.0921 | −0.1(−0.2,0.0) | 0.0812 | Yellow |
| Valine | –0.4147 | 0.0351 | −0.1(−0.2,−0.0) | 0.0367 | Yellow |
| Methionine Sulfoxide | –0.4009 | 0.0424 | −0.1(−0.2,0.0) | 0.0512 | Yellow |
| Hexenoylcarnitine (C6:1) | 0.3445 | 0.0848 | Green-yellow | ||
| aLPC a C24 | 0.4601 | 0.0180 | 0.1(0.0,0.3) | 0.0236 | Green-yellow |
| LPC a C26 | 0.4021 | 0.0417 | 0.1(0.0,0.2) | 0.0510 | Green-yellow |
| LPC a C28 | 0.3666 | 0.0655 | 0.1(0.0,0.3) | 0.0730 | Green-yellow |
| bPC aa C34:1 | 0.4041 | 0.0406 | 0.2(0.0,0.3) | 0.0584 | Green-yellow |
| PC aa C34:3 | 0.3897 | 0.0491 | 0.1(0.0,0.2) | 0.0724 | Green-yellow |
| PC aa C36:1 | 0.3501 | 0.0796 | Green-yellow | ||
| PC aa C36:2 | 0.4238 | 0.0309 | 0.2(0.0,0.3) | 0.0431 | Green-yellow |
| PC aa C36:3 | 0.4388 | 0.0249 | 0.2(0.0,0.3) | 0.0369 | Green-yellow |
| PC aa C38:3 | 0.3748 | 0.0592 | 0.1(0.0,0.2) | 0.0829 | Green-yellow |
| PC aa C38:5 | 0.3479 | 0.0816 | Green-yellow | ||
| PC aa C40:2 | 0.4232 | 0.0312 | 0.2(0.0,0.3) | 0.0419 | Green-yellow |
| PC aa C40:3 | 0.3589 | 0.0718 | 0.1(0.0,0.3) | 0.0976 | Green-yellow |
| PC aa C40:4 | 0.3532 | 0.0767 | Green-yellow | ||
| PC aa C40:5 | 0.3363 | 0.0930 | Green-yellow | ||
| PC aa C42:6 | 0.3401 | 0.0891 | Green-yellow | ||
| cPC ae C30:0 | 0.4160 | 0.0346 | 0.2(0.0,0.3) | 0.0495 | Green-yellow |
| PC ae C34:1 | 0.3875 | 0.0505 | 0.1(0.0,0.3) | 0.0702 | Green-yellow |
| PC ae C38:2 | 0.5777 | 0.0020 | 0.3(0.1,0.4) | 0.0033 | Green-yellow |
| PC ae C38:3 | 0.3817 | 0.0543 | 0.1(0.0,0.3) | 0.0749 | Green-yellow |
| PC ae C40:3 | 0.3604 | 0.0705 | 0.2(0.0,0.3) | 0.0952 | Green-yellow |
| PC ae C42:1 | 0.4554 | 0.0194 | 0.1(0.0,0.3) | 0.0330 | Green-yellow |
| PC ae C42:2 | 0.3621 | 0.0691 | Green-yellow | ||
| PC ae C42:4 | 0.3299 | 0.0998 | Green-yellow | ||
| Octadecadienylcarnitine (C18:2) | 0.3572 | 0.0732 | Blue | ||
According to common lipid nomenclature, aLPC stands for lysophosphatidylcholine with a single fatty acid chain, bPC aa stands for Phosphatidylcholine diacyl (two fatty acid chains) and cPC ae stands for Phosphatidylcholine acyl-alkyl. The lipid species are described as CX:Y where X is the length of the carbon chain C, Y is the number of double bonds; “a” means the acyl chain is attached via an ester bond to the backbone while “e” means the attachment is via an ether bond.