|
Angiogenesis
|
| CD151 [44] |
rAAV, local |
Rat |
Increased VEGF expression and improved left ventricular function |
| VEGF [45-49] |
Adenovirus, local |
Rat, sheep |
Improved ejection fraction; reduced myocardial fibrosis |
| β-adrenoceptor [50] |
Ad |
rats |
Activation of VEGF pathway for increased angiogenesis and global contractility |
| Fibroblast growth factor 9 [51, 52] |
Ad |
mice |
Conditional expression of FGF9 promotes myocardial vascularization and hypertrophy with enhanced systolic function and reduced heart failure mortality after MI. |
| Endothelial nitric oxide synthase [53-56] |
Ad |
rat |
eNOS provided cardiac protection after myocardial infarction injury through inhibition of cardiac apoptosis and collagen deposition, and suppression of TGF-β1 |
| Stromal cell-derived factor or CXCR4 [57, 58] |
Ad |
Rat |
SDF-1 alpha could improve cardiac structure and function after Myocardial infarction through angiogenic and anti-fibrotic actions. |
| Hepatic growth factor [59-61] |
Ad |
Rabbit, rat, canine |
improved left ventricular ejection fraction and fractional shortening, reduced the fibrotic area, and increased the capillary density in the risk area. |
| apoA-I [62] |
Ad |
mice |
Increased endothelial progenitor number and function and the peak rate of isovolumetric relaxation by AdapoA-I |
|
SERCA2a expression
|
| SERCA2a [63, 64] |
AAV1; Lentivirus |
Sheep, rat |
Improved contractility, reduced myocyte apoptosis and myocyte hypertrophy |
| antisense phospholamban (asPLB) [22] |
AAV |
rat |
enhanced myocardium SERCA activity; prevented the progression of heart failure |
| Urocortin-2 [65] |
AAV8 |
mice |
increased LV systolic and diastolic function |
| Small ubiquitin-like modifier 1 (SUMO-1) [66] |
AAV1 |
swine |
improved cardiac function and stabilized LV volumes |
| S100A1 [67] |
AAV9, |
porcine |
Prevented heart failure and reduced scar side |
|
Cardiomyocyte preservation and regeneration
|
| Stem cell factor [68] |
Adenovirus |
Swine |
Recruitment of cKit+ cells, improved cardiac function |
| Connexin43 [69] |
Ad |
pig |
Targeted manipulation of Cx43 levels improved conduction velocity and reduced ventricular tachycardia susceptibility. |
| G protein-coupled receptor kinase 2 (GRK2) [70, 71] |
scAAV |
Sheep, pig |
preservation of regional and global systolic function |
