FIGURE 4.

Cluster analysis of tissue damage in a cohort of 14 TBI patients displayed with color coding representing the frequency of damage noted in different regions. (A): Averages of 14 binary images in which each subject has been compared voxel by voxel to the entire healthy cohort using R2t*. A value of 0.5 means that particular voxel was significantly lower than controls in 50% of images (in 7 of 14 mTBI patients). The arrow points to a cluster of abnormal voxels with the highest degree of commonality among the mTBI subjects, in left posterior insula. (B) Number of clusters vs. number of patients contributing to overlap. (C) Spatial location of region containing posterior insula selected from 26 functional ROIs defined in previously published rs-fcfMRI analysis.