Fig. 1.

Incorporating STZ and HFD induced serious diabetes and secondary bone loss

(a) Hyperglycemia was induced by STZ. (b) Massive bone loss occurred. (c) Bone fragility was increased in diabetic rats. Altered histomorphology (d) and compromised microarchitecture (e) of the lumbar vertebrae were caused by diabetes. In (d), scale bar: 200 µm (upper) and 100 µm (below). STZ: streptozotocin; HFD: high-fat/sugar diet; FBG: fasting blood glucose; BMD: bone mineral density; BMC: bone mineral content; BV/TV: relative bone volume (bone volume/total volume); Tb.Th: trabecula thickness; BS/BV: relative bone surface (bone surface/bone volume); CON: control; DOP: diabetic osteoporosis; W0, D3&4, W4, W8, W14: Week 0, Days 3 and 4, Week 4, Week 8, Week 14. All data are expressed as mean±SD (n=5). ^** P<0.01, vs. CON