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. 2019 Sep 10;10(2):17–28. doi: 10.4291/wjgp.v10.i2.17

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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Programmed cell death protein 1 inhibitor-associated colitis. A: This colon biopsy reveals lamina propria expansion by lymphoplasmacytic infiltrate. Crypt distortion, crypt abscess, and cryptitis are prominent in the mucosa. In the stroma, a significantly increased eosinophilic infiltrate is observed; B: In another case of immune checkpoint inhibitors-related colitic mucosa, a subluminal collagen band thickening is prominent as observed in collagenous colitis. (Hematoxylin and eosin original magnification × 20, a scale bar represents 500 µm).