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Network of gp130-interacting signaling pathways. This figure illustrates the network of integral signaling pathways that are aberrantly activated in a variety of cancers, as well as in BTC. Mitogen-activated protein kinases (MAPK), phosphoinositide 3-kinase (PI3K), and Janus kinase/signal transducer and activator of transcription (Jak/STAT) signaling cascades cross talk and contribute to tumor growth, proliferation and treatment resistance.
