Summary of findings for the main comparison. NSAIDs versus placebo (control).
| NSAIDs versus placebo (control) | ||||||
| Patient or population: women with heavy menstrual bleeding Intervention: NSAIDs Comparison: placebo | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Control | NSAIDs | |||||
| MBL (mL/cycle) | — | The mean MBL (mL/cycle) in the intervention groups was 124 lower (186.36 to 61.64 lower) | — | 11 (1 study) | ⊕⊕⊝⊝ Lowa | — |
| Proportion of women with no subjective improvement in MBL | Study population | OR 0.08 (0.03 to 0.18) | 80 (1 study) | ⊕⊕⊝⊝ Lowb,c | — | |
| 800 per 1000 | 242 per 1000 (107 to 419) | |||||
| Moderate | ||||||
| 800 per 1000 | 242 per 1000 (107 to 419) | |||||
| Quality of life | No study reported this outcome | |||||
| Number of days' bleeding | No study reported this outcome | |||||
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; MBL: menstrual blood loss; NSAID: non‐steroidal anti‐inflammatory drug; OR: odds ratio. | ||||||
| GRADE Working Group grades of evidence High quality: further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: we are very uncertain about the estimate. | ||||||
aDowngraded two levels for imprecision (very small trial). bDowngraded one level for imprecision (single trial). cDowngraded one level for risk of bias (no explanation was provided).