Summary of findings 6. NSAIDs versus progesterone‐releasing intrauterine system (control).
| NSAIDs versus progesterone‐releasing intrauterine system (control) | ||||||
| Patient or population: women with heavy menstrual bleeding Intervention: NSAIDs Comparison: progesterone‐releasing intrauterine system | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Control | NSAIDs | |||||
| MBL (mL/cycle) | — | The mean MBL (mL/cycle) in the intervention groups was 4 lower (31.23 lower to 23.23 higher) | — | 16 (1 study) | ⊕⊕⊝⊝ Lowa,b | — |
| Number of days' bleeding | — | The mean duration of menstruation (days) in the intervention groups was 5 lower (6.08 to 3.92 lower) | — | 16 (1 study) | ⊕⊕⊝⊝ Lowa,b | — |
| Quality of life | No study reported this outcome | |||||
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; MBL: menstrual blood loss; NSAID: non‐steroidal anti‐inflammatory drug. | ||||||
| GRADE Working Group grades of evidence High quality: further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: we are very uncertain about the estimate. | ||||||
aDowngraded one level for risk of bias (randomisation method and allocation concealment not reported). bDowngraded one level for imprecision (one small trial).