Grover 1990.
Methods | Randomisation method not stated Double‐blind placebo‐controlled trial with parallel groups 80 women randomised No loss to follow‐up given but details of numbers randomised sketchy No power calculation made |
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Participants | India 80 women aged 19–50 years with a subjective complaint of menorrhagia and normal cervical cytology and secretory endometrium (after D&C) Exclusion criteria: local pelvic causes of bleeding |
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Interventions | Group 1: MFA 500 mg 3 times daily for 5 days of menstruation or until menstruation ceased, n = 40 Group 2: placebo same dosage regimen, n = 40 Duration: 3 consecutive cycles |
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Outcomes | "Relief" of menorrhagia Number of days bleeding |
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Notes | Not stated if ITT analysis No details given regarding measurement of "relief" of menorrhagia No data given for number of days bleeding in placebo group Author could not be contacted for clarification |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not stated |
Allocation concealment (selection bias) | Unclear risk | Unclear risk |
Blinding (performance bias and detection bias) All outcomes | Low risk | Double blind |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No dropouts reported |
Other bias | Unclear risk | No details given regarding measurement of "relief" of menorrhagia No data given for number of days bleeding in placebo group Author could not be contacted for clarification |