Table 1.
Characteristics of the research objects
| LC (n = 255) | CHB (n = 70) |
HCC (n = 40) |
HCs (n = 12) |
P value | ||
|---|---|---|---|---|---|---|
| Decompensated (n = 135) |
Compensated (n = 120) |
|||||
| Male* (%) | 96 (71.1%) | 84 (70%) | 51 (72.9%) | 32 (80%) | 9 (75%) | 0.145 |
| Age (year) | 63 (53.5–68) | 58 (50–62) | 49 (40–54) | 55.5 (39.25–66) | 50 (40.25–51.5) | 0.217 |
| HBeAg* (+), n(%) | 90 (66.7%) | 63 (52.5%) | 49 (70%) | 20 (50%) | NA | 0.152 |
| HBsAg | 4416 (3325–7081) | 4453 (3566–6266) | 5746 (2926–7081) | 4478.5 (3785–62,00) | NA | 0.081 |
| HBV-DNA* (+), n(%) | 99 (73.3%) | 90 (75%) | 59 (84.3%) | 32 (80%) | NA | 0.095 |
| ALT (IU/L) | 78.5 (63–129.5) | 111.5 (72.25–237.75) | 282 (238–468) | 66.5 (39.5–238.25) | 31 (24–34.5) | 0.000 |
| AST (IU/L) | 70.5 (51–96) | 86.5 (51.25–113.5) | 210.5 (183–359) | 53 (36.25–133.75) | 33 (25.25–37.75) | 0.015 |
| TBIL (μmol/L) | 39.1 (26.2–58.7) | 36.85 (23.85–49.45) | 20.9 (14.6–27.5) | 37 (19–73.25) | 13.25 (12.525–15.225) | 0.003 |
| ALB (g/L) | 31.35 (29.32–34.95) | 34.75 (32.4–36.9) | 44.6 (42.4–51) | 36.9 (31–43.63) | 47.6 (43.525–51.775) | 0.000 |
| PTA (%) | 67 (60–84) | 81.5 (74–90.75) | 92 (89.5–104) | 79.5 (64.5–90) | 91 (85.75–101.25) | 0.000 |
| Cr (μmol/L) | 75 (66.5–89.75) | 74 (66.5–86.5) | 76.5 (70–87) | 88 (70.25–92.25) | 70.5 (64.25–79.75) | 0.216 |
| WBC (109/L) | 4.82 (3.16–9.34) | 5.87 (4.48–7.29) | 6.64 (5.28–7.53) | 4.57 (3.315–5.65) | 6.85 (5.0–7.66) | 0.383 |
| HGB (g/L) | 119.5 (107–135.75) | 130 (117–140.75) | 148 (145–151) | 130 (108–136) | 146.5 (135.75–149.75) | 0.000 |
| PLT (109/L) | 90.5 (55–105) | 101 (88.25–144.5) | 168.5 (145–205) | 124 (76–200) | 197.5 (176.5–239.5) | 0.000 |
| SBP*, (n,%) | 21 (15.6%) | NA | NA | NA | NA | NA |
| Ascites*, (n,%) | 112 (83%) | NA | NA | NA | NA | NA |
| GI bleeding*, (n,%) | 27 (20%) | NA | NA | NA | NA | NA |
| HE*, (n,%) | 18 (13.3%) | NA | NA | NA | NA | NA |
| Child-pugh A/B/C*, n(%) | 0/90/45 (0/66.7%/33.3%) | 72/48/0 (60%/40%/0%) | NA | NA | NA | 0.000 |
HBeAg Hepatitis B e antigen, HBsAg Hepatitis B surface antigen, ALT Alanine aminotransferase, AST Aspartate aminotransferase, TBIL Total bilirubin, ALB Albumin, PTA Prothrombin activity; Cr Creatinine, WBC White blood cell, HGB Haemoglobin, PLT Platelet, SBP Spontaneous bacterial peritonitis, GI bleeding, Gastrointestinal bleeding, HE Hepatic encephalopathy
Quantitative variables were expressed as the median (centile 25; centile 75)
* Categorical variables were expressed as n (%)