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. 2019 Sep 18;7:255. doi: 10.1186/s40425-019-0734-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Blood-circulating MDSC enumeration in PDAC patients. a-b Flow cytometry analysis of circulating myeloid cells in whole blood of two independent cohorts of PDAC patients (b PDAC n = 21, HD = 8; c PDAC n = 23, HD = 9): monocytes (CD14⁺CD15⁻), MDSC1 (CD14⁺IL-4Rα⁺), MDSC4 (CD14⁺HLA-DR^low/−), granulocytes (CD15⁺CD14⁻), MDSC2 (CD15⁺IL-4Rα⁺) and MDSC3 (LIN⁻HLA-DR⁻CD33⁺SSC^high). c Flow cytometry analysis of circulating M-MDSCs (MDSC1, CD14⁺IL-4Rα⁺; MDSC4, CD14⁺HLA-DR^low/−) and e-MDSCs (MDSC3, LIN⁻HLA-DR⁻CD33⁺SSC^high) in PDAC patients (n = 73) compared to healthy donors (HD; n = 28). M-MDSC percentages were evaluated on frozen PBMCs, whereas e-MDSCs on the whole blood. Statistical analysis was performed by ANOVA test