Table 3.

The top 8 GO terms enriched by the 266 DNA methylation driven genes in prostate cancer

Category	Term	Count	p value	Genes
BP	GO:0055114 ~ oxidation–reduction process	25	2.13E−06	STEAP4, ME3, OXA1L, GLUD1, DUOX1, PAH, HPDL, ALDH3A1, ALDH1A3, GPX3, HAAO, FASN, GPX7, DHCR24, FAXDC2, MAOB, CRYZ, CDO1, RDH5, CYBA, CYP27A1, AKR1B1, TMLHE, AOX1, CYBRD1
CC	GO:0070062 ~ extracellular exosome	66	6.38E−06	STEAP4, RARRES2, RPS2, SYNGR2, CANT1, GSTM2, DES, APOD, GPX3, LTF, PI15, ZDHHC1, BST2, CFTR, EEF2, CD40, CD38, KRT17, KRT15, TMEM106A, CYBRD1, HSPB1, SERPINB1, NEU1, CSTA, MFAP4, WFDC2, GSTP1, ACP5, PAH, CD74, B3GNT8, KRT5, ITGB8, KRT7, ALDH1A3, ENTPD5, FASN, RPL3, HAAO, ANGPTL1, RPL7A, MARS, BHMT2, S100A16, LGALS3, KLK2, KLK3, HIST1H2BH, MAOB, KLK1, CRYZ, ANXA2, PROM1, ORM1, ACSM1, C1ORF116, PKP1, PHB2, RAB34, AKR1B1, CAPG, AOX1, ALDH2, SLC46A3, PON3
MF	GO:0009055 ~ electron carrier activity	7	0.001504105	ACOX2, CYBA, AOX1, AKR1B1, MAOB, ALDH2, HAAO
BP	GO:0000302 ~ response to reactive oxygen species	5	0.0019364	CYBA, APOD, GPX3, GPX7, GSTP1
MF	GO:0004030 ~ aldehyde dehydrogenase [NAD(P)+] activity	3	0.002720156	ALDH1A3, ALDH2, ALDH3A1
MF	GO:0004602 ~ glutathione peroxidase activity	4	0.002838234	GSTM2, GPX3, GPX7, GSTP1
BP	GO:0042178 ~ xenobiotic catabolic process	3	0.003748861	GSTM1, GSTM2, CRYZ
BP	GO:0060349 ~ bone morphogenesis	4	0.005820424	SP5, LTF, ACP5, RIPPLY2