Table 4.
Pathway enriched by the 266 DNA methylation driven genes
| Pathway | External_id | Members_input_overlap | p-value | q-value | Size |
|---|---|---|---|---|---|
| Drug metabolism—cytochrome P450 | hsa00982 | AOX1; GSTM1; GSTM2; ALDH3A1; MAOB; GSTP1; ALDH1A3 | 6.59E−05 | 0.003828899 | 70 |
| Phenylalanine metabolism | hsa00360 | PAH; MAOB; ALDH3A1; ALDH1A3 | 9.23E−05 | 0.003828899 | 17 |
| Histidine metabolism | hsa00340 | MAOB; ALDH3A1; ALDH2; ALDH1A3 | 0.000320403 | 0.008864472 | 23 |
| Glutathione metabolism | hsa00480 | GSTM1; GSTM2; GPX3; GSTP1; GPX7 | 0.00114281 | 0.023713299 | 54 |
| Tyrosine metabolism | hsa00350 | AOX1; ALDH3A1; ALDH1A3; MAOB | 0.001836818 | 0.030491186 | 36 |
| Tryptophan metabolism | hsa00380 | MAOB; HAAO; ALDH2; AOX1 | 0.002722806 | 0.037665486 | 40 |
| Metabolism of xenobiotics by cytochrome P450 | hsa00980 | GSTM1; GSTM2; ALDH3A1; GSTP1; ALDH1A3 | 0.00433977 | 0.051457275 | 74 |
| Chemical carcinogenesis | hsa05204 | GSTM1; GSTM2; ALDH3A1; GSTP1; ALDH1A3 | 0.007094498 | 0.073605418 | 82 |